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Mouse model would have predicted toxicity of drug that killed 5 in 1993 clini...

15 Apr 2014 at 4:21pm
Over 20 years after the fatal fialuridine trial, a study published this week in PLOS Medicine demonstrates that mice with humanized livers recapitulate the drug's toxicity. The work suggests that this mouse model should be added to the repertoire of tools used in preclinical screening of drugs for liver toxicity before they are given to human participants in clinical trials.

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